Construction and study of the properties of a veterinary medicine based on silymarin and gold nanoparticles

Authors

  • Dmitry Alekseevich Soldatov Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov
  • Natalia Igorevna Skvortsova Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov
  • Anna Dmitrievna Klyukina Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov
  • Mikhail Andreevich Chekunov Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov
  • Ekaterina Dmitrievna Chekunova Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov

DOI:

https://doi.org/10.28983/asj.y2023i8pp92-96

Keywords:

silymarin, nanoparticles, colloidal gold, gold nanoparticles

Abstract

Research on nanomaterials is currently very promising, thanks to them we can deliver the necessary substance, bypassing the barriers of the body. Silymarin has an anti-inflammatory effect due to its antioxidant properties, which have been repeatedly confirmed by experiments. The work was carried out on the basis of the Department of "Animal Diseases and VSE" and the CCP "Molecular Biology" of the Vavilov University. The work consisted of several stages, where we synthesized the drug silymarin-gnp, obtained polyclonal antibodies for silymarin, and carried out antibody labeling. And they were engaged in the detection of silymarin in the cells of the reticuloendothelial system. Thus, the study of the created conjugate of silymarin and colloidal gold nanoparticles made it possible to determine that animals immunized with the resulting drug are able to produce antibodies to it, and the sizes of nanoparticles in it do not exceed 20-23 nm.

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Published

2023-08-31

Issue

No. 8 (2023)

Section

Zootechnics and veterinary

License

Copyright (c) 2023 The Agrarian Scientific Journal

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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