Dynamics of cytokine activity of cerebrospinal fluid and blood serum of carnivores with pain syndrome
DOI:
https://doi.org/10.28983/asj.y2021i1pp52-55Keywords:
pain syndrome, cytokines, cats, dogs, pain assessment, cerebrospinal fluid, serum, enzyme-linked immunosorbent assayAbstract
New data on the mechanisms of pain syndrome development in dogs and cats were obtained, in particular, the role of anti - inflammatory cytokines: interleukin-4 (IL-4), interleukin-6 (IL - 6), interferon - gamma (IFN - gamma), tumor necrosis factor - alpha (TNF-alfa) in the formation and manifestation of this pathology was determined. The results obtained allow us to assess the dynamics of the immune status of animals with pain syndrome. Cytokines: IL-4, IL-6, and IFN - gamma showed high significance in the diagnosis of pain syndrome. Thus, the values of IL-4 in the cerebrospinal fluid and blood serum in dogs in the first experimental group were 3.5 times and 3.4 times higher in the second experimental group than in the control, in cats of the first experimental group-4.3 and 4.6 times in the second experimental group. As well as IL-4, both IL - 6 and IFN - gamma showed their high activity, in contrast to TNF-alfa, which was less sensitive to changes in pain syndrome.
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Ковалева О.Н., Ащеулова Т.В. Фактор некроза опухолей альфа и апоптоз при патологии сердечно-сосудистой системы. – Харьков: Оригинал, 2003. – 170 с.
Руденко А.А. Цитокиновый профиль сыворотки крови у собак с эндокардиозом митрального клапана // Ветеринария. – 2017. – № 10. – С. 49–55.
С-реактивный белок при острой соматической боли у новорождённых и прозревших крыс / В.Г. Овсянников [и др.] // Цитокины и воспаление. – 2015. – Т.14. – № 1. – С. 24–26.
BSAVA Manual of canine and feline anaesthesia and analgesia. Second edition, 2010, P. 17–25.
Bujak-Gizycka B. and others. Beneficial effect of amantadine on postoperative pain reduction and consumption of morphine in patients subjected to elective spine surgery. Pain Med., 2012 Mar: 13(3), P. 459–465.
De Vito V. and others. Pharmacokinetic profiles of the analgesic flupirtine in dogs after the administration of four pharmaceutical formulations. Vet Anaesth Analg., 2014, P. 10–18.
Feline Cardiology. 4th Ed. Philadelphia: Saunders -Elseiver Inc. 2008, P. 443.
Fox S. in M. Chronic pain small animal medicine. - 2010, P. 8-13.
Kroin J.S. Multimodal analgesia for controlling acute postoperative pain. Asokumar Buvanendran.- 2009, P. 12-16.
Theodore J. Molecular and Cell Biology of Pain. Price, Gregory Dussor, 2015, P. 9–8.
Tilleу L.P., Smith F.W.K., Oyama M.A., Sleeper M.M. Manual of Canine and Felint Cardiology. 4 th edn. St. Louis: Sauders, 2008, P. 49–76.
Zois N.E., Moesgaard S.G., Kjelgaard-Hansen M. et al. Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease // Vet. J., 2012,192(1), P.106–111.
WSAVA guidelines for recognition, assessment and treatment of pain. K. Mathews and others, 2014, P. 5–9.
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