Effect of a compound based on an aqueous solution of fullerene C60 on hematological parameters of white rats

Abstract

The article is devoted to the study of the effect of a compound based on an aqueous solution of fullerene C₆₀ on the hematological parameters of white rats. The experiment was carried out on three groups of animals. The first group served as a control. The second group was injected with 1 ml of an aqueous solution of Fullerene C₆₀ (1 mg / ml of DV), 150 mg of resveratrol – 25 mg, betoin hydrochloride – 10 mg. The third group received 1 ml of an aqueous solution of Fullerene C₆₀ (1 mg/ml of DV), 2500 mg of resveratrol, 1000 mg of betoin hydrochloride. It was determined that the animals of the second group had a significant increase in the number of erythrocytes by 11.8% and the hemoglobin content by 14.8% relative to the control values. In white rats of the third group, there were no significant differences with the control. In animals of the second group, the number of rod-shaped neutrophils and monocytes increased by 10 and 9.3%, respectively, relative to the control. No significant differences were found in animals of the third group. The number of segmented neutrophils after the introduction of an aqueous solution of fullerene C₆₀ increased by 12.4% (group 2 animals) and 6.1% (group 3 animals). It was revealed that the compound based on an aqueous solution of fullerene C60 has a pronounced effect on the hematological parameters of the body of white rats. The most effective dose was 1 ml of an aqueous solution of Fullerene C₆₀ (1 mg / ml of DV), 150 mg of resveratrol – 25 mg, betoin hydrochloride – 10 mg, after administration of which an increase in the number of erythrocytes by 11.8% and the hemoglobin content by 14.8% relative to the control values, the number of rod-shaped neutrophils and monocytes by 10 and 9.3%, respectively, and the number of segmented neutrophils by 12.4%.